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Chromatin

Definition
AI-generated

Chromatin is the complex of genomic DNA with histones and other proteins that packages the genome inside the nucleus.

Topics
Molecular biology
Related
Candidate cis-Regulatory Element (cCRE) Chromatin Accessibility Quantitative Trait Locus (caQTL) Chromosome

Why it matters in GWAS

Noncoding GWAS hits often overlap enhancers and other regulatory elements defined by chromatin assays (e.g. ATAC-seq, DNase-seq, ChIP-seq), motivating integration of chromatin state with genetic association.

Example usage

"Open chromatin marks at the locus supported a regulatory mechanism for the association signal."

Candidate cis-Regulatory Element (cCRE) Chromatin Accessibility Quantitative Trait Locus (caQTL) Chromosome Cis-Regulatory Element (CRE) Enhancer Promoter Transcriptional Silencer Transcription Start Site (TSS) Epigenetics Expression Quantitative Trait Locus (eQTL) Noncoding Variant Roadmap Epigenomics Consortium
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Allis CD, Jenuwein T. (2016). The molecular hallmarks of epigenetic control. Nat Rev Genet.
← Chromatin Immunoprecipitation Sequencing (ChIP-seq) Chromatin Accessibility Quantitative Trait Locus (caQTL) →

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