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Assay for Transposase-Accessible Chromatin (ATAC-seq)

Definition
AI-generated

ATAC-seq inserts sequencing adapters into open chromatin regions using a transposase, producing a genome-wide map of chromatin accessibility with relatively low input requirements.

Topics
Sequencing and omics tech
Synonyms
Assay for transposase-accessible chromatin
Related
Colocalization Encyclopedia of DNA Elements (ENCODE) Fine-Mapping

Why it matters in GWAS

ATAC-seq helps define regulatory regions and cell-type-specific accessibility, supporting interpretation of GWAS loci in noncoding DNA and prioritization of causal variants.

Example usage

"ATAC-seq peaks overlapped the credible-set SNPs in immune cell types."

Colocalization Encyclopedia of DNA Elements (ENCODE) Fine-Mapping Roadmap Epigenomics
Related-term network

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References

  • Buenrostro JD, Giresi PG, Zaba LC, Chang HY, Greenleaf WJ. (2013). Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position. Nat Methods.
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