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Transcriptional Silencer

Definition
AI-generated

A transcriptional silencer is a cis-regulatory DNA element that represses transcription of one or more genes, often via recruitment of repressive complexes and histone-modifying activities.

Topics
Molecular biology
Synonyms
silencer transcriptional suppressor element (informal: suppressor)
Plural
silencers
Related
Chromatin Cis-Regulatory Element (CRE) Enhancer

Why it matters in GWAS

Repressive regulatory variation can produce eQTL and chromatin effects opposite to enhancer gain-of-function narratives; fine-mapped variants in silencer-like regions may require repression-aware functional assays.

Example usage

"Functional interpretation integrated Transcriptional Silencer evidence with GWAS signals in relevant cell states."

Chromatin Cis-Regulatory Element (CRE) Enhancer Expression Quantitative Trait Locus (eQTL) Noncoding Variant Promoter
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Ogbourne S, Antalis TM. (1998). Transcriptional control and human disease. Crit Rev Biochem Mol Biol.
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