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Transcription Start Site (TSS)

Definition
AI-generated

The transcription start site (TSS) is the genomic position where RNA polymerase II initiates transcription of a transcript, defining the 5′ end of the first exon relative to that promoter usage.

Topics
Molecular biology
Synonyms
TSS
Plural
transcription start sites; TSSs
Related
Canonical Transcript Transcription Factor (TF) CAGE-seq

Why it matters in GWAS

Variants near the TSS and core promoter alter initiation, eQTL effects, and promoter chromatin; distance to TSS is a common axis in cis-eQTL and annotation pipelines.

Example usage

"The lead variant was 35 bp upstream of the annotated TSS in the MANE Select transcript."

Canonical Transcript Transcription Factor (TF) CAGE-seq Expression Quantitative Trait Locus (eQTL) Promoter RNA Sequencing (RNA-seq)
Related-term network

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Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Andersson R, et al. (2014). An atlas of active enhancers across human cell types and tissues. Nature.
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