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Cis-Regulatory Element (CRE)

Definition
AI-generated

A cis-regulatory element (CRE) is a noncoding DNA segment on the same chromosome as its target gene(s) that modulates transcription—classically promoters, enhancers, silencers, and insulators—through binding of transcription factors and chromatin regulators.

Topics
Molecular biology
Synonyms
CRE cis-regulatory module (related)
Plural
cis-regulatory elements; CREs
Related
Candidate cis-Regulatory Element (cCRE) Chromatin Chromatin Accessibility Quantitative Trait Locus (caQTL)

Why it matters in GWAS

Functional interpretation of noncoding associations often amounts to identifying which CRE classes are disrupted; catalogs such as ENCODE’s registry of candidate cis-regulatory elements (cCREs) provide standardized coordinates and biochemical classifications for overlap testing.

Example usage

"We annotated credible-set SNPs against a union of promoter and enhancer CREs from matched cell types."

Candidate cis-Regulatory Element (cCRE) Chromatin Chromatin Accessibility Quantitative Trait Locus (caQTL) Enhancer Encyclopedia of DNA Elements (ENCODE) Noncoding Variant Promoter Transcriptional Silencer Transcription Start Site (TSS)
Related-term network

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References

  • Maston GA, Evans SK, Green MR. (2006). Transcriptional regulatory elements in the human genome. Annu Rev Genomics Hum Genet.
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