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Chromatin Immunoprecipitation Sequencing (ChIP-seq)

Definition
AI-generated

ChIP-seq maps genome-wide binding of proteins such as transcription factors and histone modifications by immunoprecipitating chromatin fragments and sequencing the associated DNA.

Topics
Sequencing and omics tech
Synonyms
Chromatin immunoprecipitation sequencing
Related
Colocalization Encyclopedia of DNA Elements (ENCODE) Fine-Mapping

Why it matters in GWAS

ChIP-seq annotations from resources like ENCODE help interpret noncoding GWAS variants by linking them to active enhancers, promoters, and regulatory elements in relevant cell types.

Example usage

"H3K27ac ChIP-seq tracks highlighted candidate enhancers near the lead variant."

Colocalization Encyclopedia of DNA Elements (ENCODE) Fine-Mapping Noncoding Variant
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Johnson DS, et al. (2007). Genome-wide mapping of in vivo protein-DNA interactions. Science.
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