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Epigenetics

Definition
AI-generated

Epigenetics refers to heritable or long-lasting changes in gene function that are not caused by DNA sequence changes themselves—commonly involving DNA methylation, histone modifications, and chromatin accessibility.

Topics
Molecular biology
Related
Chromatin Chromatin Accessibility Quantitative Trait Locus (caQTL) Central Dogma

Why it matters in GWAS

Integrating methylation QTLs (meQTLs) and chromatin data with GWAS can nominate regulatory mechanisms for noncoding associations and clarify environment-sensitive pathways.

Example usage

"At this locus, Epigenetics annotations were used to prioritize plausible biological mechanisms."

Chromatin Chromatin Accessibility Quantitative Trait Locus (caQTL) Central Dogma Epigenome Epigenomics Expression Quantitative Trait Locus (eQTL) Methylation Quantitative Trait Locus (mQTL) Noncoding Variant Roadmap Epigenomics Consortium
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Allis CD, Jenuwein T. (2016). The molecular hallmarks of epigenetic control. Nat Rev Genet.
← Ratio Epigenome →

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