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Locus

Definition
AI-generated

A locus (plural loci) is a specific position or region in the genome, often identified by a chromosomal coordinate or a named gene interval.

Topics
Core genetics
Plural
loci
Related
Allele Fine-Mapping Genome-Wide Association Study (GWAS)

Why it matters in GWAS

GWAS results are reported as significant loci—regions where variants statistically associate with a trait—before fine-mapping narrows candidate causal variants within each interval.

Example usage

"The lead SNP on chromosome 1 defined a 200 kb risk locus containing three protein-coding genes."

Allele Fine-Mapping Genome-Wide Association Study (GWAS) Linkage Disequilibrium (LD) Single Nucleotide Polymorphism (SNP)
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Uffelmann E, et al. (2021). Genome-wide association studies. Nat Rev Methods Primers. https://doi.org/10.1038/s43586-021-00056-9
← Local Ancestry Locus heterogeneity →

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