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Enhancer

Definition
AI-generated

An enhancer is a cis-regulatory DNA segment—often distal to the target gene—that increases transcription rate when bound by activators and associated co-factors, frequently in a tissue-specific manner.

Topics
Molecular biology
Plural
enhancers
Related
Candidate cis-Regulatory Element (cCRE) Chromatin Chromatin Accessibility Quantitative Trait Locus (caQTL)

Why it matters in GWAS

A large fraction of trait-associated noncoding variants fall in enhancer states defined by Roadmap/ENCODE-style annotations; overlap with caQTL peaks and eQTL target genes motivates enhancer–promoter linkage and CRISPR follow-up.

Example usage

"The credible set overlapped a monocyte-specific H3K27ac enhancer 80 kb upstream of the gene body."

Candidate cis-Regulatory Element (cCRE) Chromatin Chromatin Accessibility Quantitative Trait Locus (caQTL) Cis-Regulatory Element (CRE) CRISPR Expression Quantitative Trait Locus (eQTL) Noncoding Variant Promoter Roadmap Epigenomics Consortium Transcriptional Silencer
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Pennacchio LA, et al. (2013). Enhancers: five essential questions. Nat Rev Genet.
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