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VDJ sequencing

Definition
AI-generated

VDJ sequencing (V(D)J sequencing) is targeted or amplicon sequencing of immunoglobulin or T-cell receptor loci after V, (D), and J segment recombination, producing reads that reconstruct rearranged CDR3-containing sequences for clonotype inference and immune repertoire sequencing workflows.

Topics
Sequencing and omics tech
Synonyms
V(D)J sequencing
Related
B cell receptor sequencing (BCR-seq) CDR3 Class switch recombination

Why it matters in GWAS

Receptor sequencing supplies detailed lymphocyte phenotypes—clonal structure and hypermutation—that can be mapped to germline HLA and immunogenetics loci implicated by association studies of infection, vaccine response, and autoimmunity.

Example usage

"VDJ sequencing of sorted B cells quantified class-switched clones after booster immunization."

B cell receptor sequencing (BCR-seq) CDR3 Class switch recombination Clonotype Immune repertoire sequencing Somatic hypermutation T Cell Receptor Sequencing
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References

  • Six A, et al. (2013). The past, present, and future of immune repertoire biology - the rise of next-generation repertoire analysis. Front Immunol.
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