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Clonotype

Definition
AI-generated

A clonotype is a distinct adaptive immune receptor sequence (commonly defined by V(D)J rearrangement and CDR3 amino acid or nucleotide sequence) identifying a clonal lineage of B or T cells in immune repertoire sequencing data.

Topics
Molecular biology Sequencing and omics tech
Related
B cell receptor sequencing (BCR-seq) CDR3 Clonal expansion

Why it matters in GWAS

Clonotype-level summaries connect cellular immune dynamics to germline variation when cohorts have both GWAS and repertoire profiling, for example in vaccine or autoimmune studies.

Example usage

"The expanded clonotype tracked longitudinally matched the public database CDR3 motif."

B cell receptor sequencing (BCR-seq) CDR3 Clonal expansion Immune repertoire sequencing V(D)J sequencing
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References

  • Six A, et al. (2013). The past, present, and future of immune repertoire biology - the rise of next-generation repertoire analysis. Front Immunol.
← Clone Coalescent Theory →

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