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CDR3

Definition
AI-generated

CDR3 (complementarity-determining region 3) is the hypervariable segment of the immunoglobulin or T-cell receptor chain formed at the V–(D)–J junction; its sequence largely defines epitope contact and is the standard core identifier for clonotype clustering in repertoire analysis.

Topics
Molecular biology
Related
Clonotype Somatic hypermutation V(D)J sequencing

Why it matters in GWAS

CDR3-based definitions align immune repertoire phenotypes across studies, supporting integration with germline HLA and immunoglobulin gene polymorphisms implicated by association mapping.

Example usage

"Clonotypes were collapsed by identical amino acid CDR3 within each V gene family."

Clonotype Somatic hypermutation V(D)J sequencing
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References

  • Giudicelli V, Chaume D, Lefranc MP. (2005). IMGT/GENE-DB: a comprehensive database for human and mouse immunoglobulin and T cell receptor genes. Nucleic Acids Res.
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