Skip to content

B cell receptor sequencing (BCR-seq)

Definition
AI-generated

Amplicon or capture sequencing of immunoglobulin rearrangements reconstructing clonotypes and somatic hypermutation—immune repertoire layer orthogonal to germline GWAS.

Topics
Sequencing and omics tech
Related
T Cell Receptor Sequencing Single Cell Sequencing Recombination

Why it matters in GWAS

Bioinformatics methods determine how variants, expression, and epigenetic state are measured and summarized—shaping GWAS covariates, multi-omic integration, and functional follow-up.

Example usage

"B cell receptor sequencing identified expanded clonotypes after vaccination, complementing germline GWAS of antibody response."

T Cell Receptor Sequencing Single Cell Sequencing Recombination
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Lesk AM. (2019). Introduction to Bioinformatics. Oxford University Press.
← Autozygosity Backcross →

Last updated (UTC · Git history)