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Class switch recombination

Definition
AI-generated

Class switch recombination (CSR) replaces the immunoglobulin heavy-chain constant region (isotype) while retaining the same variable region, redirecting effector function (for example from IgM to IgG or IgA) through DNA recombination between switch regions.

Topics
Molecular biology
Synonyms
CSR
Related
B cell receptor sequencing (BCR-seq) Somatic hypermutation V(D)J sequencing

Why it matters in GWAS

CSR is central to durable antibody responses; germline variants affecting switch machinery or signaling can intersect with GWAS of infection, vaccine response, and IgE-related traits when combined with repertoire or serology data.

Example usage

"BCR-seq read pairs spanning the switch region supported class switch recombination from IgM to IgG1 in the expanded clone."

B cell receptor sequencing (BCR-seq) Somatic hypermutation V(D)J sequencing
Related-term network

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References

  • Stavnezer J, Guikema JE, Schrader CE. (2008). Mechanism and regulation of class switch recombination. Annu Rev Immunol.
← Cis-Regulatory Element (CRE) ClinVar →

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