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Immune repertoire sequencing

Definition
AI-generated

Immune repertoire sequencing (Rep-seq) profiles adaptive immune receptors by high-throughput sequencing of V(D)J rearrangements in B or T cells, yielding clonotype frequencies, diversity, and somatic alteration patterns across samples and time.

Topics
Sequencing and omics tech
Synonyms
Rep-seq
Related
B cell receptor sequencing (BCR-seq) Clonal expansion Clonotype

Why it matters in GWAS

Germline variation influences infection, autoimmunity, and vaccine response; repertoire layers (clonal expansion, mutation, isotype usage) provide phenotypes that can be integrated with GWAS of immune traits when both are measured.

Example usage

"Immune repertoire sequencing after vaccination revealed expanded clonotypes linked to HLA background from prior GWAS."

B cell receptor sequencing (BCR-seq) Clonal expansion Clonotype Genome-Wide Association Study (GWAS) Somatic hypermutation T Cell Receptor Sequencing V(D)J sequencing
Related-term network

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References

  • Six A, et al. (2013). The past, present, and future of immune repertoire biology - the rise of next-generation repertoire analysis. Front Immunol.
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