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Epigenomics

Definition
AI-generated

Epigenomics is the genome-wide profiling of epigenetic marks and chromatin organization—e.g. bisulfite sequencing for DNA methylation, ChIP-seq for histones, and ATAC-seq or DNase-seq for accessibility.

Topics
Sequencing and omics tech
Related
Assay for Transposase-Accessible Chromatin (ATAC-seq) Bisulfite Sequencing ChIP-seq

Why it matters in GWAS

Epigenomic maps annotate regulatory sequence; integrating them with GWAS and mQTL/caQTL data supports cell-type–specific interpretation of noncoding associations.

Example usage

"We intersected fine-mapped SNPs with ATAC-seq peaks from matched primary immune cell epigenomics."

Assay for Transposase-Accessible Chromatin (ATAC-seq) Bisulfite Sequencing ChIP-seq Epigenome Epigenetics Methylation Quantitative Trait Locus (mQTL)
Related-term network

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Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Roadmap Epigenomics Consortium, et al. (2015). Integrative analysis of 111 reference human epigenomes. Nature.
← Epigenome Epistasis →

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