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Epistasis

Definition
AI-generated

Epistasis (gene–gene interaction) describes situations where the phenotypic effect of a variant at one locus depends on alleles at another locus.

Topics
Core genetics
Related
Complex Disease Genetic Heterogeneity Genome-Wide Association Study (GWAS)

Why it matters in GWAS

Standard SNP-by-SNP GWAS has limited power for high-order interactions; detected marginal effects may mask or reflect underlying epistatic architecture in pathways.

Example usage

"Functional follow-up considered Epistasis when interpreting variable genotype-to-phenotype relationships."

Complex Disease Genetic Heterogeneity Genome-Wide Association Study (GWAS) Omnigenic Model Pleiotropy
Related-term network

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Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Mackay TFC, Moore JH. (2014). Why epistasis is important for tackling complex human disease genetics. Genome Med.
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