Skip to content

Bisulfite Sequencing

Definition
AI-generated

Bisulfite sequencing treats DNA with bisulfite to convert unmethylated cytosines, then sequences the result to map cytosine methylation (often CpG) at base resolution.

Topics
Sequencing and omics tech
Related
Genome-Wide Association Study (GWAS) Noncoding Variant Variant Annotation

Why it matters in GWAS

Methylation integrates genetics and environment; bisulfite sequencing supports EWAS and interpretation of GWAS hits in regulatory regions when combined with genotype and phenotype data.

Example usage

"We profiled CpG methylation by bisulfite sequencing at loci associated with the trait."

Genome-Wide Association Study (GWAS) Noncoding Variant Variant Annotation Whole-Genome Sequencing (WGS)
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Cokus SJ, et al. (2008). Shotgun bisulphite sequencing of the Arabidopsis genome reveals DNA methylation patterning. Nature.
← Biotinylation Blacklisted region →

Last updated (UTC · Git history)