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Whole-Genome Sequencing (WGS)

Definition
AI-generated

Whole-genome sequencing reads chromosomal DNA broadly (exonic, intronic, regulatory), enabling discovery of SNVs, indels, and many structural variants at base resolution depending on coverage and algorithms.

Topics
Sequencing and omics tech
Related
Coverage Genotype Genotyping Array

Why it matters in GWAS

WGS reference panels improve imputation, enable rare-variant association and CNV analysis, and reduce ascertainment bias relative to fixed arrays, at higher cost and informatics burden.

Example usage

"Deep WGS at 30× was available for 5,000 participants in the nested sub-study."

Coverage Genotype Genotyping Array Long-Read Sequencing Low-Pass Sequencing Paired-End Sequencing Short-Read Sequencing Variant Calling Whole-Exome Sequencing (WES)
Related-term network

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Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

← Whole-genome bisulfite sequencing (WGBS) Wild-Type Allele →

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