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Low-Pass Sequencing

Definition
AI-generated

Low-pass sequencing is whole-genome sequencing performed at low average coverage, often below standard deep WGS, with genotypes later refined by imputation.

Topics
Sequencing and omics tech
Related
Coverage Genotype Imputation GLIMPSE2

Why it matters in GWAS

Low-pass sequencing can be a cost-effective alternative to arrays for common-variant GWAS, especially when paired with strong reference panels and imputation methods.

Example usage

"The cohort used 4x low-pass sequencing followed by imputation to generate genome-wide dosages."

Coverage Genotype Imputation GLIMPSE2 Genotyping Array Imputation Reference Panel Whole-Genome Sequencing (WGS)
Related-term network

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References

  • Li JH, et al. (2021). Low-pass sequencing increases the power of GWAS and decreases measurement error of polygenic risk scores compared to genotyping arrays. Genome Res.
  • Sun Q, Li Y. (2026). Advances in haplotype phasing and genotype imputation. Nat Rev Genet. https://doi.org/10.1038/s41576-025-00895-2
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