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Paired-End Sequencing

Definition
AI-generated

Paired-end sequencing reads both ends of the same DNA fragment, producing two reads with known orientation and approximate insert size.

Topics
Sequencing and omics tech
Related
Read Short-Read Sequencing Whole-Genome Sequencing (WGS)

Why it matters in GWAS

Paired-end data improve read mapping, indel detection, and resolution in repetitive regions, which generally leads to more reliable variant discovery.

Example usage

"The WGS data were generated with 150 bp paired-end sequencing on an Illumina platform."

Read Short-Read Sequencing Whole-Genome Sequencing (WGS)
Related-term network

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References

  • Metzker ML. (2010). Sequencing technologies: the next generation. Nat Rev Genet.
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