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Whole-genome bisulfite sequencing (WGBS)

Definition
AI-generated

Bisulfite conversion plus genome-wide sequencing for base-resolution DNA methylation at most C contexts coverage allows.

Why it matters in GWAS

Bioinformatics methods determine how variants, expression, and epigenetic state are measured and summarized—shaping GWAS covariates, multi-omic integration, and functional follow-up.

Example usage

"Quality-controlled Whole-genome bisulfite sequencing (WGBS) data were used to prioritize robust loci and downstream functional follow-up."

References

  • Lesk AM. (2019). Introduction to Bioinformatics. Oxford University Press.

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