Skip to content

Wild-Type Allele

Definition
AI-generated

Wild-type allele is the allele considered standard or canonical in a given biological or experimental context, often defined historically or by convention in a model system.

Topics
Core genetics
Related
Mutant Allele Reference Allele Alternative Allele

Why it matters in GWAS

In human GWAS, "wild-type" is often less precise than reference/effect/risk labels and can be ambiguous across populations. Use explicit allele coding (REF/ALT, effect allele) for reproducible statistical interpretation.

Example usage

"Functional assays compared the mutant construct against the wild-type allele background."

Mutant Allele Reference Allele Alternative Allele Effect Allele Risk Allele
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Griffiths AJF, et al. (2015). Introduction to Genetic Analysis. W. H. Freeman.
← Whole-Genome Sequencing (WGS) Winner's Curse →

Last updated (UTC · Git history)