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Coverage

Definition
AI-generated

Coverage is the amount of sequencing data overlapping a genomic position or region, often summarized as mean depth across the genome, exome, or targeted panel.

Topics
Sequencing and omics tech
Related
Low-Pass Sequencing Read Depth Variant Calling

Why it matters in GWAS

Coverage strongly affects genotype accuracy, rare-variant sensitivity, and the quality of reference panels used for imputation or downstream association analyses.

Example usage

"The sequencing subset was generated at 30x mean coverage to support high-confidence variant discovery."

Low-Pass Sequencing Read Depth Variant Calling Whole-Exome Sequencing (WES) Whole-Genome Sequencing (WGS)
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Koboldt DC. (2020). Best practices for variant calling in clinical and population sequencing. Nat Methods.
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