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Reduced-representation bisulfite sequencing (RRBS)

Definition
AI-generated

Methyl-CpG profiling targeting restriction-enriched CpG-dense subsets; lower cost than WGBS for methylation QTL or pilot epigenetic layers.

Topics
Sequencing and omics tech
Related
Bisulfite Sequencing Methylation Quantitative Trait Locus Epigenome

Why it matters in GWAS

Bioinformatics methods determine how variants, expression, and epigenetic state are measured and summarized—shaping GWAS covariates, multi-omic integration, and functional follow-up.

Example usage

"Quality-controlled Reduced-representation bisulfite sequencing (RRBS) data were used to prioritize robust loci and downstream functional follow-up."

Bisulfite Sequencing Methylation Quantitative Trait Locus Epigenome
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Lesk AM. (2019). Introduction to Bioinformatics. Oxford University Press.
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