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Paralog

Definition
AI-generated

Paralogs are homologous genes related by duplication within a genome or lineage—segmental or whole-genome duplication, tandem arrays, or retrocopy—after which copies can diverge in sequence, regulation, or function.

Topics
Evolutionary genetics
Related
Copy Number Variant (CNV) Genetic Divergence Homology

Why it matters in GWAS

Gene families and paralogs complicate fine-mapping, rare-variant aggregation, and expression interpretation: signal may tag one member while function is shared or compensated by paralogs; dosage sensitivity and redundancy affect predictions.

Example usage

"The association mapped near a tandem paralog cluster, so we tested all copies for cis-eQTL effects."

Copy Number Variant (CNV) Genetic Divergence Homology Ortholog Phylogeny
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Ohno S. (1970). Evolution by Gene Duplication. Springer.
← Parabricks Paralogous →

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