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Homology

Definition
AI-generated

Homology describes descent from a common ancestor: homologous genes or sequences share evolutionary origin even if their functions or sequences have diverged.

Topics
Evolutionary genetics
Related
Common Ancestor Ortholog Paralog

Why it matters in GWAS

Functional interpretation of coding and regulatory hits often relies on homologous sites across species (conservation) or gene families; miscalling homology blurs ortholog versus paralog mapping in comparative and model-organism follow-up.

Example usage

"Genotype QC and interpretation explicitly accounted for Homology status at candidate loci."

Common Ancestor Ortholog Paralog Phylogeny
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Fitch WM. (2000). Homology: a personal view on some of the problems. Trends Genet.
← Homologous Homology-directed repair (HDR) →

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