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Paralogous

Definition
AI-generated

Paralogous genes arise by duplication within a lineage and are homologous, but are not orthologs across species; see [Paralog](paralog.md).

Topics
Evolutionary genetics
Related
Paralog Ortholog Homology

Why it matters in GWAS

Gene-family expansions can place association signal near one paralog while the causal gene is another family member.

Example usage

"Fine-mapping excluded the paralogous copy on chromosome 12."

Paralog Ortholog Homology
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Hartl DL, Clark AG. (2007). Principles of Population Genetics. Sinauer Associates.
  • Jobling MA, Hurles ME, Tyler-Smith C. (2013). Human Evolutionary Genetics. Garland Science.
← Paralog Partial derivative →

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