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Ortholog

Definition
AI-generated

Orthologs are homologous genes (or sequences) in different species that arose by speciation from a single ancestral gene and typically retain related function.

Topics
Evolutionary genetics
Related
Common Ancestor Homology Paralog

Why it matters in GWAS

Cross-species functional follow-up, conservation screens, and model-organism experiments map human GWAS genes to orthologs; misannotation between orthologs and paralogs can misdirect mechanistic interpretation.

Example usage

"We validated the GWAS gene’s role using a loss-of-function allele in the mouse ortholog."

Common Ancestor Homology Paralog Phylogeny Speciation
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Koonin EV. (2005). Orthologs, paralogs, and evolutionary genomics. Annu Rev Genet.
← Origin of replication Orthologous →

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