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Immunotherapy

Definition
AI-generated

Immunotherapy mobilizes the immune system against disease—most prominently checkpoint inhibitors, adoptive cell therapies, vaccines, and cytokines in oncology, with growing applications in autoimmunity and infection.

Topics
Precision medicine
Related
Genome-Wide Association Study (GWAS) HLA Region Precision Medicine

Why it matters in GWAS

Germline GWAS of immune-related traits, drug toxicity, and infection outcomes highlight HLA and innate immune loci that modify response; tumor immunotherapy trials increasingly integrate somatic and germline data. Ancestry-aware imputation and careful phenotype definitions (e.g. irAEs) affect replicability.

Example usage

"Germline HLA imputation quality was evaluated before testing association with immunotherapy response."

Genome-Wide Association Study (GWAS) HLA Region Precision Medicine Precision Oncology Trans-Ancestry GWAS
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References

  • Rosenberg SA, Restifo NP. (2015). Adoptive cell transfer as personalized immunotherapy for human cancer. Science.
← Immune repertoire sequencing Imputation Quality Metric →

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