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Clonal expansion

Definition
AI-generated

Clonal expansion is the selective proliferation of lymphocytes bearing a given antigen receptor, producing increased abundance of one or a few clonotypes detectable as elevated read counts or frequencies in V(D)J or repertoire sequencing.

Topics
Molecular biology Sequencing and omics tech
Related
Clonotype Immune repertoire sequencing V(D)J sequencing

Why it matters in GWAS

Expansion metrics summarize immune responses and autoreactivity; combined with germline genotypes they help interpret HLA and immunogenetics associations in infection, vaccination, and autoimmune disease contexts.

Example usage

"Massive clonal expansion of a single TCRβ clonotype coincided with drug-induced hypersensitivity."

Clonotype Immune repertoire sequencing V(D)J sequencing
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References

  • Six A, et al. (2013). The past, present, and future of immune repertoire biology - the rise of next-generation repertoire analysis. Front Immunol.
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