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Central Dogma

Definition
AI-generated

The central dogma of molecular biology describes the usual flow of information from DNA to RNA to protein: DNA is transcribed to RNA, and RNA is translated into a polypeptide.

Topics
Molecular biology
Related
Antisense Codon Epigenetics

Why it matters in GWAS

GWAS variants are annotated by whether they fall in coding, regulatory, or splicing regions—layers between genotype and phenotype that connect DNA variation to RNA and protein function.

Example usage

"The discussion links DNA variation to RNA and protein changes, following the central dogma framework."

Antisense Codon Epigenetics Exome RNA Sequencing (RNA-seq) Transcript Assembly
Related-term network

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Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Crick F. (1970). Central dogma of molecular biology. Nature.
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