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Dominant Genetic Model

Definition
AI-generated

A dominant model compares carriers of at least one copy of the minor (or tested) allele to homozygous reference individuals, collapsing heterozygotes with homozygote alternate.

Topics
Core genetics
Related
Additive Genetic Model Genotype Heterozygote

Why it matters in GWAS

It can fit loci with dominant disease mechanisms but is used less than the additive default because it spends degrees of freedom and is sensitive to allele frequency; rarely the primary genome-wide scan.

Example usage

"Secondary analyses tested a Dominant Genetic Model framework to compare with additive effect estimates."

Additive Genetic Model Genotype Heterozygote Homozygote Recessive Genetic Model
Related-term network

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References

  • Clarke GM, et al. (2011). Basic statistical analysis in genetic case-control studies. Nat Protoc.
← Dominance Dominant negative allele →

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