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Additive Genetic Model

Definition
AI-generated

The additive model codes genotype as the count of a reference allele (0, 1, 2) and assumes the phenotype mean shifts linearly with that count—each additional allele changes risk or trait mean by the same amount on the modeled scale.

Topics
Core genetics
Related
Dominant Genetic Model Genotype Heterozygote

Why it matters in GWAS

Standard SNP GWAS almost always tests an additive effect; dominance or recessive modes require separate parameterizations or grouping and have lower power under most architectures.

Example usage

"Primary GWAS association tests assumed an additive genetic model, coding dosage as 0/1/2 copies of the effect allele."

Dominant Genetic Model Genotype Heterozygote Homozygote Recessive Genetic Model Zygosity Effect Size
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

← Adaptive Burden Test Adenine (A) →

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