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Recessive Genetic Model

Definition
AI-generated

A recessive model tests association only for homozygotes of the alternate (or minor) allele compared with all other genotypes, requiring two copies to alter risk or trait mean.

Topics
Core genetics
Related
Additive Genetic Model Compound Heterozygote Dominant Genetic Model

Why it matters in GWAS

Recessive effects can occur at individual loci but are uncommon as the default GWAS parameterization; power is low for rare recessive alleles unless sample size or burden tests target them.

Example usage

"The analysis uses Recessive Genetic Model to quantify associations and compare alternative hypotheses."

Additive Genetic Model Compound Heterozygote Dominant Genetic Model Hardy-Weinberg Equilibrium (HWE) Heterozygote Homozygote
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References

  • Clarke GM, et al. (2011). Basic statistical analysis in genetic case-control studies. Nat Protoc.
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