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Homozygote

Definition
AI-generated

A homozygote carries two identical alleles at a diploid locus—homozygous reference (two copies of the reference allele) or homozygous alternate (two copies of the same non-reference allele).

Topics
Core genetics
Synonyms
Homozygous (adjective form)
Related
Additive Genetic Model Allele Genotype

Why it matters in GWAS

Association models compare trait distributions across genotype classes; recessive tests contrast alternate homozygotes to all others, while standard additive tests treat dose 0, 1, 2 linearly. Homozygote calls are sensitive to QC (depth, allele balance) especially at rare variants.

Example usage

"Genotype QC and interpretation explicitly accounted for Homozygote status at candidate loci."

Additive Genetic Model Allele Genotype Genotype Dosage Hemizygote Heterozygote Hardy-Weinberg Equilibrium (HWE) Recessive Genetic Model Zygosity
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References

← Homozygosity Homozygous →

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