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Dominant negative allele

Definition
AI-generated

A mutant allele that interferes with the wild-type gene product in the same cell, often producing a dominant phenotype.

Topics
Core genetics
Related
Missense Variant Loss Of Function Variant Allele

Why it matters in GWAS

These concepts shape how we expect variants to act (penetrance, heterogeneity, threshold models) and how GWAS signals should be interpreted alongside family-based evidence.

Example usage

"The replication analysis used Dominant negative allele to keep assumptions consistent across cohorts."

Missense Variant Loss Of Function Variant Allele
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Griffiths AJF, et al. (2015). An Introduction to Genetic Analysis. W. H. Freeman.
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