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Cleavage Under Targets and Tagmentation (CUT&Tag)

Definition
AI-generated

CUT&Tag profiles DNA–protein interactions by tethering a transposase-loaded adapter to antibody-bound targets on intact nuclei, tagmenting nearby DNA for sequencing—often with very low input and strong enrichment for histone marks and some factors.

Topics
Sequencing and omics tech
Synonyms
CUT&Tag
Related
ATAC-seq ChIP-seq Cleavage Under Targets and Release Using Nuclease (CUT&RUN)

Why it matters in GWAS

Accessible, high-resolution chromatin maps in relevant cell types support variant-to-regulatory-element linking for association loci, alongside ATAC-seq and ChIP-seq.

Example usage

"CUT&Tag for H3K4me3 refined promoter overlap with the credible-set variants."

ATAC-seq ChIP-seq Cleavage Under Targets and Release Using Nuclease (CUT&RUN) Chromatin
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Kaya-Okur HS, et al. (2019). CUT&Tag for efficient epigenomic profiling of small samples and single cells. Nat Commun.
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