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Credible Set

Definition
AI-generated

A credible set (often a 95% credible set) is the smallest set of variants whose posterior inclusion probabilities sum to a target coverage under a Bayesian fine-mapping model.

Topics
Population genetics
Synonyms
Credible interval (variant level; informal usage varies)
Related
Posterior Inclusion Probability (PIP) FINEMAP Fine-Mapping

Why it matters in GWAS

Credible sets communicate fine-mapping output for follow-up sequencing, functional fine-mapping, and comparison across ancestries or methods; coverage and calibration depend on model assumptions and LD reference choice.

Example usage

"The 95% credible set contained four SNPs, all overlapping open chromatin in monocytes."

Posterior Inclusion Probability (PIP) FINEMAP Fine-Mapping Fine-Mapping from Summary Statistics Functional Fine-Mapping SuSiE Variant Annotation
Related-term network

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References

  • Schaid DJ, Chen W, Larson NB. (2018). From genome-wide associations to candidate causal variants by statistical fine-mapping. Nat Rev Genet.
  • Li Z, Zhou X. (2025). Towards improved fine-mapping of candidate causal variants. Nat Rev Genet. https://doi.org/10.1038/s41576-025-00869-4
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