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Crossing Over

Definition
AI-generated

Crossing over is the exchange of DNA between homologous chromosomes during meiosis, creating recombinant chromosomes.

Topics
Core genetics
Related
Centimorgan (cM) Chromosome Haplotype

Why it matters in GWAS

Recombination breaks up haplotypes over time; local recombination rates affect LD extent, fine-mapping resolution, and how well tagging SNPs capture untyped causal variation.

Example usage

"Hotspots of crossing over explained why LD decayed within 100 kb of the association peak."

Centimorgan (cM) Chromosome Haplotype Linkage Disequilibrium (LD) Locus
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Myers S, et al. (2010). Drive against hotspot motifs in primates implicates the PRDM9 gene in meiotic recombination. Science.
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