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Linkage Disequilibrium (LD)

Definition
AI-generated

Linkage disequilibrium (LD) is the non-random correlation of alleles at different loci.

Topics
Population genetics
Related
Allele High LD Regions Linkage Disequilibrium Proxy (LD proxy)

Why it matters in GWAS

Significant variants in GWAS often tag causal variants through LD rather than being causal themselves.

Example usage

"The lead SNP was in strong LD (r2 > 0.8) with nearby coding variants."

Allele High LD Regions Linkage Disequilibrium Proxy (LD proxy) LD Clumping LD Pruning LD Score LD Score Regression Genome-Wide Association Study (GWAS) Fine-Mapping Single Nucleotide Polymorphism (SNP)
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Slatkin M. (2008). Linkage disequilibrium - understanding the evolutionary past.
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