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Cross-validation fold

Definition
AI-generated

One partition of data used alternately as validation while other folds train—k-fold CV optimizes hyperparameters without an external set.

Why it matters in GWAS

Statistical concepts underpin GWAS significance, effect estimation, relatedness random effects, multiple testing, fine-mapping priors, and post-GWAS multivariate methods.

Example usage

"Each cross-validation fold preserved case-control balance and ancestry composition to avoid optimistic performance estimates."

References

  • Casella G, Berger RL. (2002). Statistical Inference. Duxbury Press.
  • Wasserman L. (2004). All of Statistics. Springer.

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