Skip to content

Cryptic Relatedness

Definition
AI-generated

Cryptic relatedness is unrecognized familial relationship among study participants that is not captured in the recorded pedigree or study metadata.

Topics
Population genetics
Related
Identity by Descent (IBD) Kinship Coefficient PI_HAT

Why it matters in GWAS

Undetected relatives violate the independence assumptions of standard association tests and can inflate test statistics if they are neither removed nor modeled.

Example usage

"We screened for cryptic relatedness with KING and excluded one sample from each unexpectedly related pair."

Identity by Descent (IBD) Kinship Coefficient PI_HAT Relatedness Relatedness and Sample Structure
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Manichaikul A, et al. (2010). Robust relationship inference in genome-wide association studies. Bioinformatics.
  • GWASTutorial: Relatedness and sample structure.
← Crossing Over Cumulative distribution function (CDF) →

Last updated (UTC · Git history)