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Centimorgan (cM)

Definition
AI-generated

The centimorgan (cM) is a unit of genetic (recombination) distance: two loci separated by 1 cM have roughly a 1% chance of being separated by crossing over in one meiosis.

Topics
Population genetics
Related
Crossing Over Chromosome Haplotype

Why it matters in GWAS

Genetic maps in cM underpin linkage analysis and historical recombination; in association studies they complement physical maps (bp) when interpreting LD extent and historical haplotype structure.

Example usage

"The disease locus was placed within a 5 cM interval between flanking microsatellite markers."

Crossing Over Chromosome Haplotype Linkage Disequilibrium (LD) Locus
Related-term network

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References

  • Kong A, et al. (2002). A high-resolution recombination map of the human genome. Nat Genet.
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