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Capture Hi-C

Definition
AI-generated

Capture Hi-C applies sequence capture to Hi-C libraries so contacts involving targeted regions (for example exomes, disease loci, or regulatory panels) are sequenced deeply, trading genome-wide uniformity for sensitivity over intervals of interest compared with standard Hi-C.

Topics
Sequencing and omics tech
Related
Capture-C Chromatin Hi C

Why it matters in GWAS

Enriched contact data can resolve promoter–enhancer and domain context for fine-mapped loci, complementing linear proximity and eQTL evidence when prioritizing causal variants.

Example usage

"Capture Hi-C anchored on the credible set recapitulated the loop to the candidate enhancer."

Capture-C Chromatin Hi C
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Mifsud B, et al. (2015). Mapping long-range promoter contacts in human cells with high-resolution capture Hi-C. Nat Genet.
← Capture-C Carbon-14 chronology →

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