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Capture-C

Definition
AI-generated

Capture-C enriches for ligation products involving chosen bait viewpoints (often many promoters or regulatory elements) by hybrid capture before sequencing, combining oligonucleotide capture with chromosome conformation capture to map contacts at higher depth over selected loci than unbiased Hi-C at similar cost.

Topics
Sequencing and omics tech
Related
Chromatin Chromosome Conformation Capture 3C Enhancer

Why it matters in GWAS

Targeted contact maps link candidate regulatory variants to physically interacting promoters and enhancers, supporting mechanistic interpretation of noncoding association intervals.

Example usage

"Capture-C from the GWAS interval viewpoint showed looping to the gene promoter in primary T cells."

Chromatin Chromosome Conformation Capture 3C Enhancer Hi C
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Hughes JR, et al. (2014). Analysis of hundreds of cis-regulatory landscapes at high resolution in a single, high-throughput experiment. Nat Genet.
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