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Admixture

Definition
AI-generated

Admixture refers to the mixing of ancestry from previously separated populations, producing genomes with segments derived from multiple ancestral sources.

Topics
Population genetics
Related
Admixture Mapping Ancestry Introgression

Why it matters in GWAS

Admixture affects allele frequencies, linkage disequilibrium, and population structure correction, so it influences matching, PCA interpretation, and transferability of effect estimates.

Example usage

"Local ancestry tracts showed recent admixture, so association models included both global PCs and locus-specific ancestry covariates."

Admixture Mapping Ancestry Introgression Local Ancestry Polygenic Risk Score Portability Population Stratification Principal Component Analysis (PCA) Relatedness and Sample Structure
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Kachuri L, Chatterjee N, Hirbo J, et al. (2024). Principles and methods for transferring polygenic risk scores across global populations. Nat Rev Genet. https://doi.org/10.1038/s41576-023-00637-2
  • Price AL, et al. (2006). Principal components analysis corrects for stratification in GWAS.
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