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Local Ancestry

Definition
AI-generated

Local ancestry assigns each chromosomal segment of an admixed individual to one of several source ancestral populations (e.g. African vs. European along the genome), typically inferred with haplotype reference panels and models such as RFMix, LAMP, or FLARE.

Topics
Population genetics
Related
Local-Ancestry GWAS (Tractor) Admixture Admixture Mapping

Why it matters in GWAS

Local ancestry is used in admixture mapping, Tractor-style association in admixed samples, and ancestry-aware polygenic modeling; ignoring it can miss locus-specific effects and complicates cross-population PRS transfer.

Example usage

"Local Ancestry estimates were incorporated to improve portability and calibration across diverse cohorts."

Local-Ancestry GWAS (Tractor) Admixture Admixture Mapping Ancestry Polygenic Risk Score Portability Population Stratification Trans-Ancestry GWAS
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Kachuri L, Chatterjee N, Hirbo J, et al. (2024). Principles and methods for transferring polygenic risk scores across global populations. Nat Rev Genet. https://doi.org/10.1038/s41576-023-00637-2
  • Maples BK, et al. (2013). RFMix: a discriminative modeling approach for rapid and robust local-ancestry inference. Am J Hum Genet.
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