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Admixture Mapping

Definition
AI-generated

Admixture mapping tests association between a trait and local genetic ancestry—the estimated proportion of each chromosome inherited from each ancestral source population—rather than testing individual SNPs alone.

Topics
Population genetics
Related
Admixture Ancestry Genome-Wide Association Study (GWAS)

Why it matters in GWAS

In admixed cohorts, local ancestry can tag variants or haplotypes that differ in frequency between ancestral groups; it complements standard GWAS and informs polygenic score construction and interpretation in diverse populations.

Example usage

"We performed admixture mapping for asthma in Latino samples using RFMix-inferred local African, European, and Native American ancestry."

Admixture Ancestry Genome-Wide Association Study (GWAS) Local Ancestry Polygenic Risk Score Portability Population Stratification Trans-Ancestry GWAS
Related-term network

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Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Kachuri L, Chatterjee N, Hirbo J, et al. (2024). Principles and methods for transferring polygenic risk scores across global populations. Nat Rev Genet. https://doi.org/10.1038/s41576-023-00637-2
  • Freedman ML, et al. (2006). Admixture mapping identifies 8q24 as a prostate cancer risk locus in African-American men. Proc Natl Acad Sci USA.
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