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Introgression

Definition
AI-generated

Introgression is the movement of alleles from one diverged lineage or species into another’s gene pool through hybridization and backcrossing, producing mosaic genomes with tracts of foreign ancestry embedded in a predominantly native background—distinct from long-standing admixture between human groups only in degree and timescale of divergence.

Topics
Population genetics
Related
Admixture Ancestry Gene Flow

Why it matters in GWAS

Ancient or archaic introgression (e.g. Neanderthal or Denisovan segments in modern humans) creates long haplotypes with unusual frequencies and can tag regulatory or immune loci; local ancestry methods sometimes borrow from introgression-aware segment detection.

Example usage

"A replication analysis checks whether Introgression assumptions hold across cohorts."

Admixture Ancestry Gene Flow Genetic Divergence Local Ancestry Positive Selection
Related-term network

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Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Racimo F, et al. (2015). Evidence for archaic adaptive introgression in humans. Nat Rev Genet.
← Intergenic Introgressive hybridization →

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